diff --git a/bin/trait_mapping/clean_up_mappings.py b/bin/trait_mapping/clean_up_mappings.py
new file mode 100755
index 00000000..c6f2f1a1
--- /dev/null
+++ b/bin/trait_mapping/clean_up_mappings.py
@@ -0,0 +1,68 @@
+#!/usr/bin/env python3
+
+import argparse
+import csv
+import os.path
+from collections import defaultdict
+
+from cmat.trait_mapping.ols import is_current_and_in_ontology
+
+from cmat.output_generation.clinvar_to_evidence_strings import load_ontology_mapping
+
+
+def flatten_dict(d):
+    # key -> [(x1, y1), (x2, y2)] ==> [(key, x1, y1), (key, x2, y2)]
+    result = []
+    for key in d:
+        for (x, y) in d[key]:
+            result.append((key, x, y))
+    return result
+
+
+def main(mappings_file):
+    mappings, target_ontology = load_ontology_mapping(mappings_file)
+
+    obsolete_mappings = defaultdict(list)
+    multiple_mappings = {}
+    current_mappings = {}
+
+    for trait_name, mapping_list in mappings.items():
+        keep_mappings = []
+        # Remove obsolete mappings
+        for uri, label in mapping_list:
+            if not is_current_and_in_ontology(uri, target_ontology):
+                obsolete_mappings[trait_name].append((uri, label))
+            else:
+                keep_mappings.append((uri, label))
+        # Remove multiple mappings
+        if len(keep_mappings) > 1:
+            multiple_mappings[trait_name] = keep_mappings
+        else:
+            current_mappings[trait_name] = keep_mappings
+
+    # Output files
+    filename = '.'.join(os.path.basename(mappings_file).split('.')[:-1])
+    with open(f'{filename}_obsolete.csv', 'w+') as outfile:
+        writer = csv.writer(outfile, delimiter='\t')
+        obsolete_rows = flatten_dict(obsolete_mappings)
+        print(f'Removed {len(obsolete_rows)} obsolete mappings')
+        writer.writerows(obsolete_rows)
+
+    with open(f'{filename}_multiple.csv', 'w+') as outfile:
+        writer = csv.writer(outfile, delimiter='\t')
+        multiple_rows = flatten_dict(multiple_mappings)
+        print(f'Removed {len(multiple_rows)} multiple mappings')
+        writer.writerows(multiple_rows)
+
+    with open(f'{filename}_current.csv', 'w+') as outfile:
+        writer = csv.writer(outfile, delimiter='\t')
+        current_rows = flatten_dict(current_mappings)
+        print(f'{len(current_rows)} mappings remaining')
+        writer.writerows(current_rows)
+
+
+if __name__ == '__main__':
+    parser = argparse.ArgumentParser('Clean up obsolete and multiple mappings')
+    parser.add_argument('--mappings-file', required=True, help='File of latest ontology mappings to process')
+    args = parser.parse_args()
+    main(args.mappings_file)