diff --git a/requirements.txt b/requirements.txt
index 37a1d5c..b4c262e 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,4 +1,4 @@
-setuptools==40.6.2
+setuptools==65.5.1
 requests>=2.18.4,<=2.20.1
 Werkzeug==0.15.5
 pystache>=0.5.1,<=0.5.4
diff --git a/setup.py b/setup.py
index f3a45ad..f324703 100644
--- a/setup.py
+++ b/setup.py
@@ -13,6 +13,6 @@
       download_url='https://github.com/PerimeterX/perimeterx-python-wsgi/tarball/' + version,
       packages=find_packages(exclude=['dev', 'test*']),
       package_data={'perimeterx': ['templates/*']},
-      install_requires=['pystache>=0.5.1,<=0.5.4', 'requests>=2.18.4,<=2.20.1', 'setuptools==40.6.2', 'Werkzeug==0.15.5', 'pycryptodome>=3.7.2, <4.0.0'],
+      install_requires=['pystache>=0.5.1,<=0.5.4', 'requests>=2.18.4,<=2.20.1', 'setuptools==65.5.1', 'Werkzeug==0.15.5', 'pycryptodome>=3.7.2, <4.0.0'],
       classifiers=['Intended Audience :: Developers',
                    'Programming Language :: Python :: 2.7'])