diff --git a/packages/components/package-lock.json b/packages/components/package-lock.json
index 186355f862..e765c75ba1 100644
--- a/packages/components/package-lock.json
+++ b/packages/components/package-lock.json
@@ -1,12 +1,12 @@
 {
   "name": "@labkey/components",
-  "version": "6.68.0",
+  "version": "6.68.1",
   "lockfileVersion": 3,
   "requires": true,
   "packages": {
     "": {
       "name": "@labkey/components",
-      "version": "6.68.0",
+      "version": "6.68.1",
       "license": "SEE LICENSE IN LICENSE.txt",
       "dependencies": {
         "@hello-pangea/dnd": "18.0.1",
diff --git a/packages/components/package.json b/packages/components/package.json
index 7869bedd9a..7093ac4805 100644
--- a/packages/components/package.json
+++ b/packages/components/package.json
@@ -1,6 +1,6 @@
 {
   "name": "@labkey/components",
-  "version": "6.68.0",
+  "version": "6.68.1",
   "description": "Components, models, actions, and utility functions for LabKey applications and pages",
   "sideEffects": false,
   "files": [
diff --git a/packages/components/releaseNotes/components.md b/packages/components/releaseNotes/components.md
index 34b4cf0e96..0ece3a35b2 100644
--- a/packages/components/releaseNotes/components.md
+++ b/packages/components/releaseNotes/components.md
@@ -1,6 +1,11 @@
 # @labkey/components
 Components, models, actions, and utility functions for LabKey applications and pages
 
+### version 6.68.1
+*Released* 2 November 2025
+- Issue 52063: Domain designer to handle lookup to a query with a pipe character
+  - don't just split on '|', as the queryName could contain '|' characters
+
 ### version 6.68.0
 *Released* 2 November 2025
 - Add auditing of what method was used for CRUD
diff --git a/packages/components/src/internal/components/domainproperties/models.test.ts b/packages/components/src/internal/components/domainproperties/models.test.ts
index f0edf0a680..349ccd495a 100644
--- a/packages/components/src/internal/components/domainproperties/models.test.ts
+++ b/packages/components/src/internal/components/domainproperties/models.test.ts
@@ -51,6 +51,7 @@ import {
 
 import {
     acceptablePropertyType,
+    decodeLookup,
     DEFAULT_TEXT_CHOICE_VALIDATOR,
     DomainDesign,
     DomainField,
@@ -1522,3 +1523,51 @@ describe('resolveLookupQueryValue', () => {
         );
     });
 });
+
+describe('decodeLookup', () => {
+    test('base', () => {
+        let result = decodeLookup('http://www.w3.org/2001/XMLSchema#string|query');
+        expect(result.rangeURI).toBe('http://www.w3.org/2001/XMLSchema#string');
+        expect(result.queryName).toBe('query');
+
+        result = decodeLookup('http://www.w3.org/2001/XMLSchema#int|anotherQuery');
+        expect(result.rangeURI).toBe('http://www.w3.org/2001/XMLSchema#int');
+        expect(result.queryName).toBe('anotherQuery');
+
+        result = decodeLookup('http://www.w3.org/2001/XMLSchema#dateTime|dateQuery');
+        expect(result.rangeURI).toBe('http://www.w3.org/2001/XMLSchema#dateTime');
+        expect(result.queryName).toBe('dateQuery');
+    });
+
+    test('invalid', () => {
+        let result = decodeLookup(undefined);
+        expect(result.rangeURI).toBeUndefined();
+        expect(result.queryName).toBeUndefined();
+
+        result = decodeLookup('invalidStringWithoutDelimiter');
+        expect(result.rangeURI).toBe('invalidStringWithoutDelimiter');
+        expect(result.queryName).toBeUndefined();
+
+        result = decodeLookup('');
+        expect(result.rangeURI).toBe('');
+        expect(result.queryName).toBeUndefined();
+
+        result = decodeLookup('onlyDelimiter|');
+        expect(result.rangeURI).toBe('onlyDelimiter');
+        expect(result.queryName).toBe('');
+
+        result = decodeLookup('|onlyQueryName');
+        expect(result.rangeURI).toBe('');
+        expect(result.queryName).toBe('onlyQueryName');
+    });
+
+    test('multipl | delimiters', () => {
+        let result = decodeLookup('http://www.w3.org/2001/XMLSchema#string|query|extra');
+        expect(result.rangeURI).toBe('http://www.w3.org/2001/XMLSchema#string');
+        expect(result.queryName).toBe('query|extra');
+
+        result = decodeLookup('http://www.w3.org/2001/XMLSchema#int|another|query|with|pipes');
+        expect(result.rangeURI).toBe('http://www.w3.org/2001/XMLSchema#int');
+        expect(result.queryName).toBe('another|query|with|pipes');
+    });
+});
diff --git a/packages/components/src/internal/components/domainproperties/models.tsx b/packages/components/src/internal/components/domainproperties/models.tsx
index 0937d8157f..901b6b9260 100644
--- a/packages/components/src/internal/components/domainproperties/models.tsx
+++ b/packages/components/src/internal/components/domainproperties/models.tsx
@@ -1531,7 +1531,10 @@ export function getValidValuesDetailStr(validValues: string[]): string {
 }
 
 export function decodeLookup(value: string): { queryName: string; rangeURI: string } {
-    const [rangeURI, queryName] = value ? value.split('|') : [undefined, undefined];
+    // Issue 52063: don't just split on '|', as the queryName could contain '|' characters
+    const separatorIndex = value?.indexOf('|') ?? -1;
+    const rangeURI = separatorIndex === -1 ? value : value.substring(0, separatorIndex);
+    const queryName = separatorIndex === -1 ? undefined : value.substring(separatorIndex + 1);
 
     return {
         queryName,