diff --git a/cuchem/requirements.txt b/cuchem/requirements.txt
index 5dab0b9a..afa0bea2 100644
--- a/cuchem/requirements.txt
+++ b/cuchem/requirements.txt
@@ -10,7 +10,7 @@ sqlalchemy==1.3.20
 openpyxl==3.0.6
 tabulate==0.8.7
 autopep8==1.5.4
-protobuf==3.15.0
+protobuf==3.18.3
 chembl_webresource_client==0.10.2
 matplotlib==3.3.4
 waitress==2.1.2