I'm using OpenTPCast with an HTC Vive. Everything works great - until I turn on my spectator display. I use a Steam Link in "VR Mode" to provide a full-screen spectator view. When the Link is connected to the PC, trying to select things from Steam from inside VR causes the laser pointer to switch to a mouse pointer and nothing happens. If you madly click you can sometimes trigger a click. If you manage to get into an app other than Steam, things work as expected.
I'm reporting this here instead of on Steam because it doesn't happen when I'm wired.