diff --git a/google/cloud/sqlalchemy_spanner/sqlalchemy_spanner.py b/google/cloud/sqlalchemy_spanner/sqlalchemy_spanner.py
index 480747b0..4ab387a9 100644
--- a/google/cloud/sqlalchemy_spanner/sqlalchemy_spanner.py
+++ b/google/cloud/sqlalchemy_spanner/sqlalchemy_spanner.py
@@ -718,6 +718,15 @@ def visit_create_index(
                 text += " STORING (%s)" % ", ".join(
                     [self.preparer.quote(c.name) for c in storing_columns]
                 )
+
+            if options.get("null_filtered", False):
+                text = re.sub(
+                    r"(^\s*CREATE\s+(?:UNIQUE\s+)?)INDEX",
+                    r"\1NULL_FILTERED INDEX",
+                    text,
+                    flags=re.IGNORECASE,
+                )
+
         return text
 
     def get_identity_options(self, identity_options):
diff --git a/samples/null_filtered_index.py b/samples/null_filtered_index.py
new file mode 100644
index 00000000..d8d9556f
--- /dev/null
+++ b/samples/null_filtered_index.py
@@ -0,0 +1,75 @@
+# Copyright 2025 Google LLC All rights reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import uuid
+
+from sqlalchemy import create_engine, Index
+from sqlalchemy.exc import IntegrityError
+from sqlalchemy.orm import mapped_column, DeclarativeBase, Mapped, Session
+
+from sample_helper import run_sample
+
+# Shows how to create a null-filtered index.
+#
+# A null-filtered index does not index NULL values. This is useful for
+# maintaining smaller indexes over sparse columns.
+# https://cloud.google.com/spanner/docs/secondary-indexes#null-indexing-disable
+
+
+class Base(DeclarativeBase):
+    pass
+
+
+class Singer(Base):
+    __tablename__ = "singers_with_null_filtered_index"
+    __table_args__ = (
+        Index("uq_null_filtered_name", "name", unique=True, spanner_null_filtered=True),
+    )
+
+    id: Mapped[str] = mapped_column(primary_key=True, default=lambda: str(uuid.uuid4()))
+    name: Mapped[str | None]
+
+
+def null_filtered_index_sample():
+    engine = create_engine(
+        "spanner:///projects/sample-project/"
+        "instances/sample-instance/"
+        "databases/sample-database",
+        echo=True,
+    )
+    Base.metadata.create_all(engine)
+
+    # We can create singers with a name of jdoe and NULL.
+    with Session(engine) as session:
+        session.add(Singer(name="jdoe"))
+        session.add(Singer(name=None))
+        session.commit()
+
+    # The unique index will stop us from adding another jdoe.
+    with Session(engine) as session:
+        session.add(Singer(name="jdoe"))
+        try:
+            session.commit()
+        except IntegrityError:
+            session.rollback()
+
+    # The index is null filtered, so we can still add another
+    # NULL name. The NULL values are not part of the index.
+    with Session(engine) as session:
+        session.add(Singer(name=None))
+        session.commit()
+
+
+if __name__ == "__main__":
+    run_sample(null_filtered_index_sample)
diff --git a/test/mockserver_tests/null_filtered_index.py b/test/mockserver_tests/null_filtered_index.py
new file mode 100644
index 00000000..e4ca5d69
--- /dev/null
+++ b/test/mockserver_tests/null_filtered_index.py
@@ -0,0 +1,37 @@
+# Copyright 2025 Google LLC All rights reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from sqlalchemy import Index
+from sqlalchemy.orm import DeclarativeBase
+from sqlalchemy.orm import Mapped
+from sqlalchemy.orm import mapped_column
+
+
+class Base(DeclarativeBase):
+    pass
+
+
+class Singer(Base):
+    __tablename__ = "singers"
+    __table_args__ = (
+        Index("idx_name", "name"),
+        Index("idx_uq_name", "name", unique=True),
+        Index("idx_null_filtered_name", "name", spanner_null_filtered=True),
+        Index(
+            "idx_uq_null_filtered_name", "name", unique=True, spanner_null_filtered=True
+        ),
+    )
+
+    id: Mapped[str] = mapped_column(primary_key=True)
+    name: Mapped[str]
diff --git a/test/mockserver_tests/test_null_filtered_index.py b/test/mockserver_tests/test_null_filtered_index.py
new file mode 100644
index 00000000..28ed1b5d
--- /dev/null
+++ b/test/mockserver_tests/test_null_filtered_index.py
@@ -0,0 +1,80 @@
+# Copyright 2025 Google LLC All rights reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from sqlalchemy import create_engine
+from sqlalchemy.testing import eq_, is_instance_of
+from google.cloud.spanner_v1 import (
+    FixedSizePool,
+    ResultSet,
+)
+from test.mockserver_tests.mock_server_test_base import (
+    MockServerTestBase,
+    add_result,
+)
+from google.cloud.spanner_admin_database_v1 import UpdateDatabaseDdlRequest
+
+
+class TestNullFilteredIndex(MockServerTestBase):
+    """Ensure we emit correct DDL for not null filtered indexes."""
+
+    def test_create_table(self):
+        from test.mockserver_tests.null_filtered_index import Base
+
+        add_result(
+            """SELECT true
+FROM INFORMATION_SCHEMA.TABLES
+WHERE TABLE_SCHEMA="" AND TABLE_NAME="singers"
+LIMIT 1
+""",
+            ResultSet(),
+        )
+        add_result(
+            """SELECT true
+FROM INFORMATION_SCHEMA.TABLES
+WHERE TABLE_SCHEMA="" AND TABLE_NAME="albums"
+LIMIT 1
+""",
+            ResultSet(),
+        )
+        engine = create_engine(
+            "spanner:///projects/p/instances/i/databases/d",
+            connect_args={"client": self.client, "pool": FixedSizePool(size=10)},
+        )
+        Base.metadata.create_all(engine)
+        requests = self.database_admin_service.requests
+        eq_(1, len(requests))
+        is_instance_of(requests[0], UpdateDatabaseDdlRequest)
+        eq_(5, len(requests[0].statements))
+        eq_(
+            "CREATE TABLE singers (\n"
+            "\tid STRING(MAX) NOT NULL, \n"
+            "\tname STRING(MAX) NOT NULL\n"
+            ") PRIMARY KEY (id)",
+            requests[0].statements[0],
+        )
+
+        # The order of the CREATE INDEX statements appears to be
+        # arbitrary, so we sort it for test consistency.
+        index_statements = sorted(requests[0].statements[1:])
+        eq_("CREATE INDEX idx_name ON singers (name)", index_statements[0])
+        eq_(
+            "CREATE NULL_FILTERED INDEX idx_null_filtered_name ON singers (name)",
+            index_statements[1],
+        )
+        eq_("CREATE UNIQUE INDEX idx_uq_name ON singers (name)", index_statements[2])
+        eq_(
+            "CREATE UNIQUE NULL_FILTERED INDEX "
+            "idx_uq_null_filtered_name ON singers (name)",
+            index_statements[3],
+        )