diff --git a/docs/advanced-topics.md b/docs/advanced-topics.md
index 442a2318..b8c2fd64 100644
--- a/docs/advanced-topics.md
+++ b/docs/advanced-topics.md
@@ -160,6 +160,7 @@ base_options: dict = {
     "idempotent_commands": [],
     "negation_default_when": [],
     "negation_negate_with": [],
+    "negation_replace": [],
 }
 ```
 
@@ -348,6 +349,40 @@ coming soon...
 
 coming soon...
 
+#### negation_replace
+
+Used to apply exceptions on 'no' commands. This option is similar to
+per_line_sub but applied in the config removal pipeline.
+
+Mandatory parameters:
+```text
+search - regex to match and separate by groups
+replace - replaced expression used by re.sub. Can be a fixed string or a group
+          sorted in search
+```
+
+e.g. - ipv6 prefix-list commands:
+```text
+ipv6 prefix-list spine-to-leaf-v6 seq 1 permit 2801:80:3ea1:1::/64 ge 65
+no ipv6 prefix-list spine-to-leaf-v6 seq 1
+```
+
+```yaml
+negation_replace:
+- lineage:
+  - re_search: ipv6 prefix-list \b.* permit
+  search: (ipv6 prefix-list \b.* seq \b[0-9]+).(permit\b.*)
+  replace: 'no \1 '
+```
+
+```text
+original:
+no ipv6 prefix-list spine-to-leaf-v6 seq 1 permit 2801:80:3ea1:1::/64 ge 65
+
+result:
+no ipv6 prefix-list spine-to-leaf-v6 seq 1
+```
+
 ## Custom hier_config Workflows
 
 Coming soon...
diff --git a/hier_config/child.py b/hier_config/child.py
index 7caf75d5..eb552ae3 100644
--- a/hier_config/child.py
+++ b/hier_config/child.py
@@ -15,6 +15,7 @@
 
 from .base import HConfigBase
 from . import text_match
+import re
 
 if TYPE_CHECKING:
     from .root import HConfig
@@ -219,6 +220,13 @@ def negate(self) -> HConfigChild:
             if self.lineage_test(rule):
                 return self._default()
 
+        if "negation_replace" in self.options.keys():
+            for rule in self.options["negation_replace"]:
+                if self.lineage_test(rule):
+                    line = re.sub(rule["search"], rule["replace"], self.text)
+                    self.text = line
+                    return self
+
         return self._swap_negation()
 
     @property
diff --git a/hier_config/options.py b/hier_config/options.py
index 13e72018..8a82874f 100644
--- a/hier_config/options.py
+++ b/hier_config/options.py
@@ -12,6 +12,7 @@
     "idempotent_commands": [],
     "negation_default_when": [],
     "negation_negate_with": [],
+    "negation_replace": [],
 }
 ios_options: dict = {
     "style": "ios",
diff --git a/tests/fixtures/options_ios.yml b/tests/fixtures/options_ios.yml
index 92b80e6a..bde83c40 100644
--- a/tests/fixtures/options_ios.yml
+++ b/tests/fixtures/options_ios.yml
@@ -117,3 +117,7 @@ negation_default_when: []
 #   - startswith: description
 #   use: no description
 negation_negate_with: []
+
+# Negate expressions with replace: lineage expression -> negate replace
+# Use search and replace options to find and replace some line expression
+negation_replace: []