diff --git a/nexus_multiple_args/README.md b/nexus_multiple_args/README.md
new file mode 100644
index 00000000..8da0f146
--- /dev/null
+++ b/nexus_multiple_args/README.md
@@ -0,0 +1,33 @@
+This sample shows how to map a Nexus operation to a handler workflow that takes multiple input arguments. The Nexus operation receives a single input object but unpacks it into multiple arguments when starting the workflow.
+
+### Sample directory structure
+
+- [service.py](./service.py) - shared Nexus service definition
+- [caller](./caller) - a caller workflow that executes Nexus operations, together with a worker and starter code
+- [handler](./handler) - Nexus operation handlers, together with a workflow used by the Nexus operation, and a worker that polls for both workflow and Nexus tasks.
+
+### Instructions
+
+Start a Temporal server. (See the main samples repo [README](../README.md)).
+
+Run the following:
+
+```
+temporal operator namespace create --namespace nexus-multiple-args-handler-namespace
+temporal operator namespace create --namespace nexus-multiple-args-caller-namespace
+
+temporal operator nexus endpoint create \
+  --name nexus-multiple-args-nexus-endpoint \
+  --target-namespace nexus-multiple-args-handler-namespace \
+  --target-task-queue nexus-multiple-args-handler-task-queue
+```
+
+In one terminal, run the Temporal worker in the handler namespace:
+```
+uv run nexus_multiple_args/handler/worker.py
+```
+
+In another terminal, run the Temporal worker in the caller namespace and start the caller workflow:
+```
+uv run nexus_multiple_args/caller/app.py
+```
\ No newline at end of file
diff --git a/nexus_multiple_args/__init__.py b/nexus_multiple_args/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/nexus_multiple_args/caller/__init__.py b/nexus_multiple_args/caller/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/nexus_multiple_args/caller/app.py b/nexus_multiple_args/caller/app.py
new file mode 100644
index 00000000..88aadbf9
--- /dev/null
+++ b/nexus_multiple_args/caller/app.py
@@ -0,0 +1,53 @@
+import asyncio
+import uuid
+from typing import Optional
+
+from temporalio.client import Client
+from temporalio.worker import Worker
+
+from nexus_multiple_args.caller.workflows import CallerWorkflow
+
+NAMESPACE = "nexus-multiple-args-caller-namespace"
+TASK_QUEUE = "nexus-multiple-args-caller-task-queue"
+
+
+async def execute_caller_workflow(
+    client: Optional[Client] = None,
+) -> tuple[str, str]:
+    client = client or await Client.connect(
+        "localhost:7233",
+        namespace=NAMESPACE,
+    )
+
+    async with Worker(
+        client,
+        task_queue=TASK_QUEUE,
+        workflows=[CallerWorkflow],
+    ):
+        # Execute workflow with English language
+        result1 = await client.execute_workflow(
+            CallerWorkflow.run,
+            args=["Nexus", "en"],
+            id=str(uuid.uuid4()),
+            task_queue=TASK_QUEUE,
+        )
+
+        # Execute workflow with Spanish language
+        result2 = await client.execute_workflow(
+            CallerWorkflow.run,
+            args=["Nexus", "es"],
+            id=str(uuid.uuid4()),
+            task_queue=TASK_QUEUE,
+        )
+
+        return result1, result2
+
+
+if __name__ == "__main__":
+    loop = asyncio.new_event_loop()
+    try:
+        results = loop.run_until_complete(execute_caller_workflow())
+        for result in results:
+            print(result)
+    except KeyboardInterrupt:
+        loop.run_until_complete(loop.shutdown_asyncgens())
diff --git a/nexus_multiple_args/caller/workflows.py b/nexus_multiple_args/caller/workflows.py
new file mode 100644
index 00000000..940a032f
--- /dev/null
+++ b/nexus_multiple_args/caller/workflows.py
@@ -0,0 +1,30 @@
+from temporalio import workflow
+
+with workflow.unsafe.imports_passed_through():
+    from nexus_multiple_args.service import HelloInput, MyNexusService
+
+NEXUS_ENDPOINT = "nexus-multiple-args-nexus-endpoint"
+
+
+# This is a workflow that calls a nexus operation with multiple arguments.
+@workflow.defn
+class CallerWorkflow:
+    # An __init__ method is always optional on a workflow class. Here we use it to set the
+    # nexus client, but that could alternatively be done in the run method.
+    def __init__(self):
+        self.nexus_client = workflow.create_nexus_client(
+            service=MyNexusService,
+            endpoint=NEXUS_ENDPOINT,
+        )
+
+    # The workflow run method demonstrates calling a nexus operation with multiple arguments
+    # packed into an input object.
+    @workflow.run
+    async def run(self, name: str, language: str) -> str:
+        # Start the nexus operation and wait for the result in one go, using execute_operation.
+        # The multiple arguments (name and language) are packed into a HelloInput object.
+        result = await self.nexus_client.execute_operation(
+            MyNexusService.hello,
+            HelloInput(name=name, language=language),
+        )
+        return result.message
diff --git a/nexus_multiple_args/handler/__init__.py b/nexus_multiple_args/handler/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/nexus_multiple_args/handler/service_handler.py b/nexus_multiple_args/handler/service_handler.py
new file mode 100644
index 00000000..c2ddfb92
--- /dev/null
+++ b/nexus_multiple_args/handler/service_handler.py
@@ -0,0 +1,39 @@
+from __future__ import annotations
+
+import uuid
+
+import nexusrpc
+from temporalio import nexus
+
+from nexus_multiple_args.handler.workflows import HelloHandlerWorkflow
+from nexus_multiple_args.service import HelloInput, HelloOutput, MyNexusService
+
+
+# @@@SNIPSTART samples-python-nexus-handler-multiargs
+@nexusrpc.handler.service_handler(service=MyNexusService)
+class MyNexusServiceHandler:
+    """
+    Service handler that demonstrates multiple argument handling in Nexus operations.
+    """
+
+    # This is a nexus operation that is backed by a Temporal workflow.
+    # The key feature here is that it demonstrates how to map a single input object
+    # (HelloInput) to a workflow that takes multiple individual arguments.
+    @nexus.workflow_run_operation
+    async def hello(
+        self, ctx: nexus.WorkflowRunOperationContext, input: HelloInput
+    ) -> nexus.WorkflowHandle[HelloOutput]:
+        """
+        Start a workflow with multiple arguments unpacked from the input object.
+        """
+        return await ctx.start_workflow(
+            HelloHandlerWorkflow.run,
+            args=[
+                input.name,  # First argument: name
+                input.language,  # Second argument: language
+            ],
+            id=str(uuid.uuid4()),
+        )
+
+
+# @@@SNIPEND
diff --git a/nexus_multiple_args/handler/worker.py b/nexus_multiple_args/handler/worker.py
new file mode 100644
index 00000000..d12a7ee1
--- /dev/null
+++ b/nexus_multiple_args/handler/worker.py
@@ -0,0 +1,45 @@
+import asyncio
+import logging
+from typing import Optional
+
+from temporalio.client import Client
+from temporalio.worker import Worker
+
+from nexus_multiple_args.handler.service_handler import MyNexusServiceHandler
+from nexus_multiple_args.handler.workflows import HelloHandlerWorkflow
+
+interrupt_event = asyncio.Event()
+
+NAMESPACE = "nexus-multiple-args-handler-namespace"
+TASK_QUEUE = "nexus-multiple-args-handler-task-queue"
+
+
+async def main(client: Optional[Client] = None):
+    logging.basicConfig(level=logging.INFO)
+
+    client = client or await Client.connect(
+        "localhost:7233",
+        namespace=NAMESPACE,
+    )
+
+    # Start the worker, passing the Nexus service handler instance, in addition to the
+    # workflow classes that are started by your nexus operations, and any activities
+    # needed. This Worker will poll for both workflow tasks and Nexus tasks.
+    async with Worker(
+        client,
+        task_queue=TASK_QUEUE,
+        workflows=[HelloHandlerWorkflow],
+        nexus_service_handlers=[MyNexusServiceHandler()],
+    ):
+        logging.info("Worker started, ctrl+c to exit")
+        await interrupt_event.wait()
+        logging.info("Shutting down")
+
+
+if __name__ == "__main__":
+    loop = asyncio.new_event_loop()
+    try:
+        loop.run_until_complete(main())
+    except KeyboardInterrupt:
+        interrupt_event.set()
+        loop.run_until_complete(loop.shutdown_asyncgens())
diff --git a/nexus_multiple_args/handler/workflows.py b/nexus_multiple_args/handler/workflows.py
new file mode 100644
index 00000000..15bd0824
--- /dev/null
+++ b/nexus_multiple_args/handler/workflows.py
@@ -0,0 +1,32 @@
+from temporalio import workflow
+
+with workflow.unsafe.imports_passed_through():
+    from nexus_multiple_args.service import HelloOutput
+
+
+# This is the workflow that is started by the `hello` nexus operation.
+# It demonstrates handling multiple arguments passed from the Nexus service.
+@workflow.defn
+class HelloHandlerWorkflow:
+    @workflow.run
+    async def run(self, name: str, language: str) -> HelloOutput:
+        """
+        Handle the hello workflow with multiple arguments.
+
+        This method receives the individual arguments (name and language)
+        that were unpacked from the HelloInput in the service handler.
+        """
+        if language == "en":
+            message = f"Hello {name} 👋"
+        elif language == "fr":
+            message = f"Bonjour {name} 👋"
+        elif language == "de":
+            message = f"Hallo {name} 👋"
+        elif language == "es":
+            message = f"¡Hola! {name} 👋"
+        elif language == "tr":
+            message = f"Merhaba {name} 👋"
+        else:
+            raise ValueError(f"Unsupported language: {language}")
+
+        return HelloOutput(message=message)
diff --git a/nexus_multiple_args/service.py b/nexus_multiple_args/service.py
new file mode 100644
index 00000000..ccae11fd
--- /dev/null
+++ b/nexus_multiple_args/service.py
@@ -0,0 +1,34 @@
+"""
+This is a Nexus service definition that demonstrates multiple argument handling.
+
+A service definition defines a Nexus service as a named collection of operations, each
+with input and output types. It does not implement operation handling: see the service
+handler and operation handlers in nexus_multiple_args.handler.service_handler for that.
+
+A Nexus service definition is used by Nexus callers (e.g. a Temporal workflow) to create
+type-safe clients, and it is used by Nexus handlers to validate that they implement
+correctly-named operation handlers with the correct input and output types.
+
+The service defined in this file features one operation: hello, where hello
+demonstrates handling multiple arguments through a single input object.
+"""
+
+from dataclasses import dataclass
+
+import nexusrpc
+
+
+@dataclass
+class HelloInput:
+    name: str
+    language: str
+
+
+@dataclass
+class HelloOutput:
+    message: str
+
+
+@nexusrpc.service
+class MyNexusService:
+    hello: nexusrpc.Operation[HelloInput, HelloOutput]
diff --git a/tests/hello_nexus/hello_nexus_test.py b/tests/hello_nexus/hello_nexus_test.py
index f9a8807d..fecfe17c 100644
--- a/tests/hello_nexus/hello_nexus_test.py
+++ b/tests/hello_nexus/hello_nexus_test.py
@@ -8,7 +8,7 @@
 import hello_nexus.caller.app
 import hello_nexus.caller.workflows
 import hello_nexus.handler.worker
-from tests.hello_nexus.helpers import create_nexus_endpoint, delete_nexus_endpoint
+from tests.helpers.nexus import create_nexus_endpoint, delete_nexus_endpoint
 
 
 async def test_nexus_service_basic(client: Client, env: WorkflowEnvironment):
diff --git a/tests/helpers/__init__.py b/tests/helpers/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/tests/hello_nexus/helpers.py b/tests/helpers/nexus.py
similarity index 100%
rename from tests/hello_nexus/helpers.py
rename to tests/helpers/nexus.py
diff --git a/tests/nexus_multiple_args/__init__.py b/tests/nexus_multiple_args/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/tests/nexus_multiple_args/nexus_multiple_args_test.py b/tests/nexus_multiple_args/nexus_multiple_args_test.py
new file mode 100644
index 00000000..682b8f20
--- /dev/null
+++ b/tests/nexus_multiple_args/nexus_multiple_args_test.py
@@ -0,0 +1,50 @@
+import asyncio
+import sys
+
+import pytest
+from temporalio.client import Client
+from temporalio.testing import WorkflowEnvironment
+
+import nexus_multiple_args.caller.app
+import nexus_multiple_args.caller.workflows
+import nexus_multiple_args.handler.worker
+from tests.helpers.nexus import create_nexus_endpoint, delete_nexus_endpoint
+
+
+async def test_nexus_multiple_args(client: Client, env: WorkflowEnvironment):
+    if env.supports_time_skipping:
+        pytest.skip("Nexus tests don't work under the Java test server")
+
+    if sys.version_info[:2] < (3, 10):
+        pytest.skip("Sample is written for Python >= 3.10")
+
+    create_response = await create_nexus_endpoint(
+        name=nexus_multiple_args.caller.workflows.NEXUS_ENDPOINT,
+        task_queue=nexus_multiple_args.handler.worker.TASK_QUEUE,
+        client=client,
+    )
+    try:
+        handler_worker_task = asyncio.create_task(
+            nexus_multiple_args.handler.worker.main(
+                client,
+            )
+        )
+        await asyncio.sleep(1)
+        results = await nexus_multiple_args.caller.app.execute_caller_workflow(
+            client,
+        )
+        nexus_multiple_args.handler.worker.interrupt_event.set()
+        await handler_worker_task
+        nexus_multiple_args.handler.worker.interrupt_event.clear()
+
+        # Verify the expected output messages
+        assert results == (
+            "Hello Nexus 👋",
+            "¡Hola! Nexus 👋",
+        )
+    finally:
+        await delete_nexus_endpoint(
+            id=create_response.endpoint.id,
+            version=create_response.endpoint.version,
+            client=client,
+        )