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Added New AUC Pk Parameters#486

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PavanLomati merged 5 commits intohumanpred:mainfrom
PavanLomati:pavan/add-new-pk-parameters
Dec 3, 2025
Merged

Added New AUC Pk Parameters#486
PavanLomati merged 5 commits intohumanpred:mainfrom
PavanLomati:pavan/add-new-pk-parameters

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  1. Clearance (CL)
    Description: Calculate oral or IV clearance.
    Function name: pk.calc.cl
    • Existing parameters:
    cl.last, cl.all, cl.obs, cl.pred
    • New parameters added:
    cl.int.all, cl.int.inf.obs, cl.int.inf.pred, cl.int.last, cl.iv.all, cl.iv.last, cl.iv.obs, cl.iv.pred,
    cl.ivint.all, cl.ivint.last,
    cl.sparse.last

  1. Elimination Rate Constant (Kel) Description: Calculate the elimination rate constant (Kel). Function name: pk.calc.kel
    • Existing parameters:
    kel.last, kel.obs, kel.pred,
    kel.iv.last, kel.iv.obs, kel.iv.pred
    • New parameters added:
    kel.all, kel.int.all, kel.int.inf.obs, kel.int.inf.pred, kel.int.last, kel.iv.all,
    kel.ivint.all, kel.ivint.last,
    kel.sparse.last

  1. Mean Residence Time (MRT) — Oral or General Description: Calculate the mean residence time (MRT) for single-dose or linear multiple-dose data. Function name: pk.calc.mrt
    • Existing parameters:
    mrt.last, mrt.obs, mrt.pred
    • New parameters added:
    mrt.all, mrt.int.all, mrt.int.inf.obs, mrt.int.inf.pred, mrt.int.last, mrt.sparse.last

  1. Mean Residence Time (MRT) — IV Infusion Description: MRT calculation specifically for IV infusion. Function name: pk.calc.mrt.iv
    • Existing parameters:
    mrt.iv.last, mrt.iv.obs, mrt.iv.pred
    • New parameters added:
    mrt.iv.all,
    mrt.ivint.all, mrt.ivint.last

  1. Steady-State Volume of Distribution (Vss) Description: Calculate the steady-state volume of distribution (Vss). Function name: pk.calc.vss
    • Existing parameters:
    vss.iv.last, vss.iv.obs, vss.iv.pred,
    vss.last,
    vss.md.obs, vss.md.pred,
    vss.obs, vss.pred
    • New parameters added:
    vss.all, vss.int.all, vss.int.inf.obs, vss.int.inf.pred, vss.int.last, vss.iv.all,
    vss.ivint.all, vss.ivint.last,
    vss.sparse.last

  1. Terminal Volume of Distribution (Vz) Description: Calculate the terminal volume of distribution (Vz). Function name: pk.calc.vz
    • Existing parameters:
    vz.obs, vz.pred
    • New parameters added:
    vz.all, vz.int.all, vz.int.inf.obs, vz.int.inf.pred, vz.int.last, vz.iv.all, vz.iv.last, vz.iv.obs, vz.iv.pred,
    vz.ivint.all, vz.ivint.last,
    vz.last; vz.sparse.last

Description: Calculate oral or IV clearance.
Function name: pk.calc.cl
•	Existing parameters:
cl.last, cl.all, cl.obs, cl.pred
•	New parameters added:
cl.int.all, cl.int.inf.obs, cl.int.inf.pred, cl.int.last,
cl.iv.all, cl.iv.last, cl.iv.obs, cl.iv.pred,
cl.ivint.all, cl.ivint.last,
cl.sparse.last
________________________________________
2. Elimination Rate Constant (Kel)
Description: Calculate the elimination rate constant (Kel).
Function name: pk.calc.kel
•	Existing parameters:
kel.last, kel.obs, kel.pred,
kel.iv.last, kel.iv.obs, kel.iv.pred
•	New parameters added:
kel.all, kel.int.all, kel.int.inf.obs, kel.int.inf.pred, kel.int.last,
kel.iv.all,
kel.ivint.all, kel.ivint.last,
kel.sparse.last
________________________________________
3. Mean Residence Time (MRT) — Oral or General
Description: Calculate the mean residence time (MRT) for single-dose or linear multiple-dose data.
Function name: pk.calc.mrt
•	Existing parameters:
mrt.last, mrt.obs, mrt.pred
•	New parameters added:
mrt.all, mrt.int.all, mrt.int.inf.obs, mrt.int.inf.pred, mrt.int.last,
mrt.sparse.last
________________________________________
4. Mean Residence Time (MRT) — IV Infusion
Description: MRT calculation specifically for IV infusion.
Function name: pk.calc.mrt.iv
•	Existing parameters:
mrt.iv.last, mrt.iv.obs, mrt.iv.pred
•	New parameters added:
mrt.iv.all,
mrt.ivint.all, mrt.ivint.last
________________________________________
5. Steady-State Volume of Distribution (Vss)
Description: Calculate the steady-state volume of distribution (Vss).
Function name: pk.calc.vss
•	Existing parameters:
vss.iv.last, vss.iv.obs, vss.iv.pred,
vss.last,
vss.md.obs, vss.md.pred,
vss.obs, vss.pred
•	New parameters added:
vss.all, vss.int.all, vss.int.inf.obs, vss.int.inf.pred, vss.int.last,
vss.iv.all,
vss.ivint.all, vss.ivint.last,
vss.sparse.last
________________________________________
6. Terminal Volume of Distribution (Vz)
Description: Calculate the terminal volume of distribution (Vz).
Function name: pk.calc.vz
•	Existing parameters:
vz.obs, vz.pred
•	New parameters added:
vz.all, vz.int.all, vz.int.inf.obs, vz.int.inf.pred, vz.int.last,
vz.iv.all, vz.iv.last, vz.iv.obs, vz.iv.pred,
vz.ivint.all, vz.ivint.last,
vz.last; vz.sparse.last
- Changed unit.type to unit_type (correct parameter name)
- Added sparse=TRUE for sparse data parameters
@PavanLomati PavanLomati merged commit aac6a30 into humanpred:main Dec 3, 2025
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