A senotype, or senescence associated secretory phenotype, is a cellular senescence functional definition and associated multidimensional description. A senotype associates a phenotype with a disease; a set of markers (genes or proteins) expressed by cell types in an anatomic location; and an assay.
The entities and relationships of a senotype can be encoded with values from standard biomedical vocabularies. A senotype can be modeled using a knowledge graph database such as the Unified Biomedical Knowledge Graph (UBKG).
Following is a high-level model of an encoded senotype:
The Senlib database will support the definition of senotypes:
- Senotype submissions will be maintained as JSON objects. Refer to the Senotype_Submission_Schema document.
- Assertion reference information used by the Senotype editor will be maintained in various lookup tables. The lookup tables are defined in this DDL script.
CRU operations (not delete) will be managed by the Senotype Editor.
The attached Excel file simulates the user interface for the curation application.