This repository contains 3D printer (and laser cutter) files, as well as analysis and plotting code associated with the validation of the COMBO Window—a chronic cranial implant for multiscale circuit interrogation in mice.
B. J. Edelman & D. Siegenthaler et al., PLOS Biology, 2024
- Introduces a novel cranial implant that enables long-term, multimodal neural recordings in head-fixed moving mice.
- Key contributions:
- Supports multiple imaging modalities (two-photonimaging, functional ultrasound imaging, electrophysiology).
- Enables stable, chronic recordings months after implantation while maintaining high-quality optical access.
- Designed for easy fabrication and open-source sharing using 3D printing and laser cutting.
The full dataset used for validation is available on Edmond (MPG Open Science):
The 3D models, laser cutter files, and plotting code are hosted on Zenodo:
The COMBO Window is an open-source cranial implant designed for long-term multimodal neural recordings in mice. This repository provides:
- 3D printer & laser cutter files for fabrication.
- Analysis & plotting scripts for validation data.
- Open-access datasets & code for reproducibility and further development.